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Questiomycin A

CAT: 0804-HY-N8439-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8439-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases[1][2].
CAS Number
1916-59-2
Product Name Alternative
Phx-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Bacterial; HSP
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/questiomycin-a.html
Purity
99.19
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C1C(N)=CC2=NC3=C(C=CC=C3)OC2=C1
Molecular Formula
C12H8N2O2
Molecular Weight
212.20
Precautions
H315, H319, H335
References & Citations
[1]Machihara K, et al. Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78. Biochem Biophys Res Commun. 2017 Oct 7;492 (1) :33-40.|[2]Guo S, et al. Production of Antibacterial Questiomycin A in Metabolically Engineered Pseudomonas chlororaphis HT66. J Agric Food Chem. 2022 Jun 29;70 (25) :7742-7750.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HSP70

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