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N-Salicyloyltryptamine

CAT: 0804-HY-147377-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147377-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-Salicyloyltryptamine acts on voltage-dependent Na+, Ca2+, and K+ ion channels inhibitor. N-Salicyloyltryptamine inhibits K+ currents with an IC50 value of 34.6 μM (Ito) . N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect[1]-[5].
CAS Number
31384-98-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel; ERK; Guanylate Cyclase; NF-κB; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/n-salicyloyltryptamine.html
Purity
96.37
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C(C(NCCC2=CNC3=C2C=CC=C3)=O)C=CC=C1
Molecular Formula
C17H16N2O2
Molecular Weight
280.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Gasparotto J, et al Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages. Cell Biol Toxicol. 2013 Jun;29 (3) :175-87. |[2]Araújo DA, et al. N-salicyloyltryptamine, a new anticonvulsant drug, acts on voltage-dependent Na+, Ca2+, and K+ ion channels. Br J Pharmacol. 2003 Dec;140 (7) :1331-9. |[3]Veras RC, et al. N-Salicyloyltryptamine, an N-Benzoyltryptamine Analogue, Induces Vasorelaxation through Activation of the NO/sGC Pathway and Reduction of Calcium Influx. Molecules. 2018 Jan 28;23 (2) :253. |[4]Oliveira FA, et al. Anticonvulsant properties of N-salicyloyltryptamine in mice. Pharmacol Biochem Behav. 2001 Feb;68 (2) :199-202. |[5]Quintans LJ Jr, et al. Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach. J Biomed Biotechnol. 2010;2010:230745.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel

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