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Dictamine

CAT: 0804-HY-N0849-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0849-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dictamnine (Dictamine) exhibits cytotoxicity to human cervical and colon cancer cells and also has antibacterial and antifungal activities[1].
CAS Number
484-29-7
Product Name Alternative
Dictamnine; Dectamine
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Bacterial; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dictamine.html
Purity
99.60
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=C2C(OC=C2)=NC3=CC=CC=C13
Molecular Formula
C12H9NO2
Molecular Weight
199.21
Precautions
H302, H315, H319
References & Citations
[1]Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25 (9) :631-41.|[2]An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14 (10) :5895-900.|[3]Lin CY, et al. Dictamnine delivered by PLGA nanocarriers ameliorated inflammation in an oxazolone-induced dermatitis mouse model. J Control Release. 2021 Jan 10;329:731-742.|[4]Wang JY, et al. Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways. Chem Biol Interact. 2018 Dec 25;296:134-144. |[5]Yang N, et al. Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3. Biochem Pharmacol. 2023 Feb;208:115368.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Dictamnine

Dictamnine is an organic heterotricyclic compound, an organonitrogen heterocyclic compound, an oxacycle and an alkaloid antibiotic.

CAS Number484-29-7
PubChem CID68085
IUPAC Name4-methoxyfuro[2,3-b]quinoline
Molecular FormulaC12H9NO2
Molecular Weight199.20
XLogP2.7
Topological Polar Surface Area35.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count15
Formal Charge0
Complexity234
SMILES
COC1=C2C=COC2=NC3=CC=CC=C31
InChI
InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3
InChIKey
WIONIXOBNMDJFJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dictamnine
CAS: 484-29-7
CID: 68085
Formula: C12H9NO2
MW: 199.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight199.20
XLogP32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass199.063328530
Monoisotopic Mass199.063328530
Topological Polar Surface Area35.3 Ų
Heavy Atom Count15
Formal Charge0
Complexity234
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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CatalogName
T5746-01Dictamine

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