Propargyl-PEG4-acid
CAT:
804-HY-130481-02
Size:
1 g
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Propargyl-PEG4-acid
- CAS Number: 1415800-32-6
- UNSPSC Description: Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Target Antigen: PROTAC Linkers
- Type: Reference compound
- Related Pathways: PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/propargyl-peg4-acid.html
- Purity: 97.0
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: C#CCOCCOCCOCCOCCC(O)=O
- Molecular Weight: 260.28
- References & Citations: [1]Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported