PE-Labeled Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Tetramer Protein

PE-Labeled Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Tetramer Protein

• Background: Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC). Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC). Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. The Human HLA-A*0201 EBV LMP1 (YLLEMLWRL) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M and YLLEMLWRL peptide of the EBV LMP1.
• Description: PE-Labeled Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Tetramer Protein (HLP-HP2Hd) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & YLLEMLWRL peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & YLLEMLWRL).
• Specifications: PE-Labeled Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Tetramer Protein is assembled by biotinylated monomer (HLP-H82Ec) and PE-labeled streptavidin. Biotinylated Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Complex Protein is produced by co-expression of HLA and B2M loaded with EBV LMP1 peptide. Biotinylated Human HLA-A*02:01&B2M&EBV LMP1 (YLLEMLWRL) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).
• Expression Region: Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & YLLEMLWRL peptide
• Host: HEK 293
• Target: HLA-A*0201 & B2M & EBV LMP1 (YLLEMLWRL)
• Conjugation: PE Labeled
• Tag: C-10×His
• Source: Human
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Format: Powder
• Buffer: PBS, 1% BSA, pH7.4
• Additives: Trehalose
• Molecular Weight: 36.3 kDa and 11.7 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, aviod light