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Piperlongumine

CAT: 0804-HY-N2329-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2329-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Piperlongumine is a alkaloid[1], possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities[2]. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines[1]. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome[2][3].
CAS Number
20069-09-4
Product Name Alternative
Piplartine
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Apoptosis; Autophagy; Bacterial; ERK; Ferroptosis; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Piperlongumine.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CCCN1C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O
Molecular Formula
C17H19NO5
Molecular Weight
317.34
Precautions
H302, H315, H320, H335
References & Citations
[1]Karki K, et al. Piperlongumine Induces Reactive Oxygen Species (ROS) -Dependent Downregulation of Specificity Protein Transcription Factors.|[2]Wu X, e, t al. Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts. J Cell Biochem. 2018 Dec;119 (12) :10358-10364|[3]Yan Qin , et al. Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: A bulk omics research and single cell sequencing validation. Front Immunol. 2022 Nov 3;13:994828.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ERK1; ERK2

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