Pyridoxal phosphate-d5

Pyridoxal phosphate-d5

• CAS Number: 1246818-16-5
• UNSPSC Description: Pyridoxal phosphate-d5 is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; Reverse Transcriptase
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease;Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Purity: 99.30
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: C(OP(=O)(O)O)(C=1C(C=O)=C(O)C(C([2H])([2H])[2H])=NC1)([2H])[2H]
• Molecular Weight: 252.17
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7.|[3]Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported