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Chlorothymol

CAT: 0804-HY-B1606-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1606-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chlothymol is a potent positive modulator of the GABAA receptor subunit LGC-37, anticonvulsant, and antibacterial agent. Chlothymol inhibits Pentylenetetrazol-induced c-fos expression. Chlothymol inhibits the growth of Methicillin -resistant Staphylococcus aureus (MRSA) strains, including LAC, with an MIC of 32 μg/mL. Chlorothymol has protective effects against epileptic seizures in various mouse models[1][2].
CAS Number
89-68-9
Product Name Alternative
Chlorthymol; 6-Chlorothymol
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
AP-1; Bacterial; GABA Receptor
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chlorothymol.html
Purity
99.70
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C1=C(O)C=C(C)C(Cl)=C1)C
Molecular Formula
C10H13ClO
Molecular Weight
184.67
Precautions
H315, H319, H335
References & Citations
[1]Alistair Jones, et al. A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 2020 Oct;61 (10) :2106-2118. |[2]Kim BC, et al. 4-Chloro-2-Isopropyl-5-Methylphenol Exhibits Antimicrobial and Adjuvant Activity against Methicillin-Resistant Staphylococcus aureus. J Microbiol Biotechnol. 2022 Jun 28;32 (6) :730-739.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

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BA1581-100Chlorothymol
C19540-016-Chlorothymol
FC70467-01(4) 6-Chlorothymol

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