Chlorothymol

• Description:

  Chlothymol is a potent positive modulator of the GABAA receptor subunit LGC-37, anticonvulsant, and antibacterial agent. Chlothymol inhibits Pentylenetetrazol-induced c-fos expression. Chlothymol inhibits the growth of Methicillin (HY-121544) -resistant Staphylococcus aureus (MRSA) strains, including LAC, with an MIC of 32 μg/mL. Chlorothymol has protective effects against epileptic seizures in various mouse models[1][2].

• Product Name Alternative:

  Chlorthymol; 6-Chlorothymol

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  AP-1; Bacterial; GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/chlorothymol.html

• Purity:

  99.70

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CC(C1=C(O)C=C(C)C(Cl)=C1)C

• Molecular Formula:

  C10H13ClO

• Molecular Weight:

  184.67

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Alistair Jones, et al. A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 2020 Oct;61 (10) :2106-2118. |[2]Kim BC, et al. 4-Chloro-2-Isopropyl-5-Methylphenol Exhibits Antimicrobial and Adjuvant Activity against Methicillin-Resistant Staphylococcus aureus. J Microbiol Biotechnol. 2022 Jun 28;32 (6) :730-739.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [89-68-9]