Chlorothymol

• UNSPSC Description:

  Chlorothymol (Chlorthymol) is a potent GABAA receptor subunit LGC-37 positive modulator. Chlorothymol is an effective anticonvulsant. Chlorothymol is protective in several mouse seizure assays, including the 6-Hz 44-mA model of pharmacoresistant seizures. Chlorothymol possess GABAergic, membrane-modifying, antioxidant and topical antiseptic properties[1].

• Target Antigen:

  Bacterial; GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/chlorothymol.html

• Purity:

  99.70

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CC(C1=C(O)C=C(C)C(Cl)=C1)C

• Molecular Weight:

  184.666

• References & Citations:

  [1]Alistair Jones, et al. A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 2020 Oct;61(10):2106-2118.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  89-68-9