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Penicillamine

CAT: 0804-HY-B0300-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0300-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Penicillamine (D- (-) -Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria[1][2][3][4].
CAS Number
52-67-5
Product Name Alternative
D- (-) -Penicillamine
UNSPSC
12352211
Hazard Statement
H361
Target
Cuproptosis; Drug Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Penicillamine.html
Purity
98.0
Solubility
DMSO : 1.43 mg/mL (ultrasonic) |H2O : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N[C@H](C(C)(S)C)C(O)=O
Molecular Formula
C5H11NO2S
Molecular Weight
149.22
Precautions
H361
References & Citations
[4]Ishak R, et, al. Penicillamine revisited: historic overview and review of the clinical uses and cutaneous adverse effects. Am J Clin Dermatol. 2013 Jun;14 (3) :223-33.|[1]Chen DB, et, al. Penicillamine increases free copper and enhances oxidative stress in the brain of toxic milk mice. PLoS One. 2012;7 (5) :e37709.|[2]Rahimi N, et, al. Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. Epilepsy Behav. 2014 Oct;39:42-7. |[3]Masson MJ, et, al. Tolerance induced by low dose D-penicillamine in the brown Norway rat model of drug-induced autoimmunity is immune-mediated. Chem Res Toxicol. 2004 Jan;17 (1) :82-94.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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