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Ferutinin

CAT: 0804-HY-125703-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125703-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities[1][2].
CAS Number
41743-44-6
UNSPSC
12352005
Target
Apoptosis; Estrogen Receptor/ERR
Type
Natural Products
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Infection; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ferutinin.html
Purity
99.23
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O[C@@H]1[C@@]2([H])[C@@](C(C)C)(O)CC[C@]2(C)CC=C(C)C1)C3=CC=C(O)C=C3
Molecular Formula
C22H30O4
Molecular Weight
358.47
References & Citations
[1]Kazuhiro Ikeda, et al. Terpenoids found in the umbelliferae family act as agonists/antagonists for ER (alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER (alpha) and ERbeta. Biochem Biophys Res Commun. 2002 Feb 22;291 (2) :354-60. |[2]Tatsiana Ilyich, et al. Ferutinin Induces Membrane Depolarization, Permeability Transition Pore Formation, and Respiration Uncoupling in Isolated Rat Liver Mitochondria by Stimulation of Ca 2+-Permeability. J Membr Biol. 2018 Aug;251 (4) :563-572.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ERα; ERβ

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