Degenerative Spermatocyte Homolog 2

• Background:

  Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. Up-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9. Belongs to the fatty acid desaturase family. DEGS subfamily. Highly expressed in skin, intestine and kidney.

• Synonyms:

  DEGS2, Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2

• UniProt:

  Q6QHC5 (Human)

• Host:

  Rabbit

• Species Reactivity:

  Human

• Conjugation:

  Unconjugated

• Type:

  Blocking Peptide

• Applications:

  WB

• Assay Principle:

  For use with DEGS2 polyclonal antibodies (Cat. No. X2356P , X2357P).

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Mizutani, Y., et al. 'Identification of the Human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.; FEBS Lett. 563:93-97(2004). 2. Omae, F., et al. 'DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine.' Biochem J. 2004 May 1;379(Pt 3):687-95. 3. Omae, F. et al. 'Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2.' FEBS Lett. 2004 Oct 8;576(1-2):63-7. 4. Enomoto, A., et al. 'Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.' Biochem J. 2006 Jul 15;397(2):289-95.

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB