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Moflomycin

CAT: 0804-HY-119827Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119827Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Moflomycin (F 860191) is a compound with strong anti-leukemic activity and low mutagenicity. Moflomycin has an antiproliferative effect on the leukemic cell line HL60 in vitro (IC50=2.9 nM) [1]. Moflomycin enhances topoisomerase II-induced DNA breaks and free radical production[2].
CAS Number
107430-03-5
Product Name Alternative
F 860191
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/moflomycin.html
Smiles
O=C(C1=C2C(O)=C3C[C@](CO)(O)C[C@H](O[C@H]4[C@H](I)[C@@H]([C@H]([C@H](C)O4)O)O)C3=C1O)C5=CC=CC=C5C2=O
Molecular Formula
C25H25IO10
Molecular Weight
612.36
References & Citations
[1]Andrivon W, et al. A new anthracycline with potent antileukemic activity exhibits reduced mutagenicity[J]. Mutation Research/Genetic Toxicology, 1995, 344 (3-4) : 135-140.|[2]Andrivon W, et al. Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity. Leuk Res. 1996 Feb;20 (2) :119-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
MBS5774244Moflomycin

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