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Avotaciclib

CAT: 0804-HY-137432-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137432-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Avotaciclib (BEY1107) is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib can be used in the research of cancer such as pancreatic cancer and lung cancer[1][2].
CAS Number
1983983-41-0
Product Name Alternative
BEY1107
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/avotaciclib.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3
Molecular Formula
C13H11N7O
Molecular Weight
281.27
References & Citations
[1]Seufferlein T, et, al. Phase I Trials in Pancreatic Cancer. Translational Pancreatic Cancer Research pp 219-232. |[2]Zhang L, et al. Suppression of cyclin-dependent kinase 1 synergizes with checkpoint kinase 2 inhibitor to promote death of non-small cell lung cancer cells with radiotherapeutic resistance. Journal of Radiation Research and Applied Sciences, 2024, 17 (2) : 100900.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CDK1
Citation 01
Cancer Cell Int. 2024 Dec 19;24 (1) :409.|J Radiat Res Appl Sci. 2024Jun, 17, 2, 100900.|Clin Sci. 2025 Oct 22;139 (20) :1163-1185.

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