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Amiselimod

CAT: 0804-HY-16734Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-16734Size:1 Each
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Description
Amiselimod (MT-1303) is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod is an orally active and high selectivity sphingosine 1-phosphate receptor-1 (S1P1) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimodis promising for research of autoimmune diseases[1][2][3][4].
CAS Number
[942399-20-4]
Product Name Alternative
MT-1303
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/amiselimod.html
Smiles
FC(F)(C1=CC(CCC(CO)(CO)N)=CC=C1OCCCCCCC)F
Molecular Formula
C19H30F3NO3
Molecular Weight
377.44
References & Citations
[1]Sugahara K, et al., Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2017 Jan;174 (1) :15-27.|[2] Kappos L, et al. Safety and efficacy of amiselimod in relapsing multiple sclerosis (MOMENTUM) : a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2016 Oct;15 (11) :1148-59. |[3]Shimano K, et al. Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells. PLoS One. 2019 Dec 5;14 (12) :e0226154. |[4]Sugahara K, et al. Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models. J Immunol Res. 2019 Dec 23;2019:5821589.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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