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Tilfrinib

CAT: 0804-HY-110244-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110244-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour[1][2].
CAS Number
1600515-49-8
UNSPSC
12352005
Target
BRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tilfrinib.html
Purity
99.39
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(NC2=C3C4=CC=CC=C4NC3=NC=C2)=C1
Molecular Formula
C17H13N3O
Molecular Weight
275.30
References & Citations
[1]Mahmoud KA, et al. Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg Med Chem Lett. 2014 Apr 15;24 (8) :1948-51.|[2]Zhang Q, Liu S, et al. ETV4 mediated tumor-associated neutrophil recruitment promotes lymphangiogenesis and lymphatic metastasis of bladder cancer[J]. 2022.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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