DNS-8254

• Description:

  DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC50 of 8 nM. DNS-8254 shows memory enhancing effects in a rat model[1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dns-8254.html

• Smiles:

  O=C (C1=CC=C (F) C (Br) =C1) N2CC (F) (F) C[C@H] (C3=CC (C) =NC4=NC=NN34) C2

• Molecular Formula:

  C18H15BrF3N5O

• Molecular Weight:

  454.24

• References & Citations:

  [1]Gomez L, et al. Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J Med Chem. 2017;60 (5) :2037-2051.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1821107-98-5