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DNS-8254

CAT: 0804-HY-120710Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120710Size:1 Each
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Description
DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC50 of 8 nM. DNS-8254 shows memory enhancing effects in a rat model[1].
CAS Number
1821107-98-5
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dns-8254.html
Smiles
O=C(C1=CC=C(F)C(Br)=C1)N2CC(F)(F)C[C@H](C3=CC(C)=NC4=NC=NN34)C2
Molecular Formula
C18H15BrF3N5O
Molecular Weight
454.24
References & Citations
[1]Gomez L, et al. Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J Med Chem. 2017;60 (5) :2037-2051.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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