DNS-8254

• Description :

  DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC50 of 8 nM. DNS-8254 shows memory enhancing effects in a rat model[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dns-8254.html

• Smiles :

  O=C(C1=CC=C(F)C(Br)=C1)N2CC(F)(F)C[C@H](C3=CC(C)=NC4=NC=NN34)C2

• Molecular Formula :

  C18H15BrF3N5O

• Molecular Weight :

  454.24

• References & Citations :

  [1]Gomez L, et al. Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J Med Chem. 2017;60 (5) :2037-2051.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1821107-98-5]