Azido-PEG24-acid

CAT: 0804-HY-140457-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-140457-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Azido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG24-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

2195075-62-6

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg24-acid.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O

Molecular Formula

C51H101N3O26

Molecular Weight

1172.35

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Chemical Information

Azido-PEG24-acid

CAS Number	2195075-62-6
PubChem CID	75535106
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Molecular Formula	C51H101N3O26
Molecular Weight	1172.4
XLogP	-2.9
Topological Polar Surface Area	273
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	28
Rotatable Bond Count	75
Heavy Atom Count	80
Formal Charge	0
Complexity	1200

SMILES

C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O

InChI

InChI=1S/C51H101N3O26/c52-54-53-2-4-58-6-8-60-10-12-62-14-16-64-18-20-66-22-24-68-26-28-70-30-32-72-34-36-74-38-40-76-42-44-78-46-48-80-50-49-79-47-45-77-43-41-75-39-37-73-35-33-71-31-29-69-27-25-67-23-21-65-19-17-63-15-13-61-11-9-59-7-5-57-3-1-51(55)56/h1-50H2,(H,55,56)

InChIKey

DLBYIOOMXALGRA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2195075-62-6

CID: 75535106

Formula: C51H101N3O26

MW: 1172.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	1172.4
XLogP3	-2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	28
Rotatable Bond Count	75
Exact Mass	1171.66733034
Monoisotopic Mass	1171.66733034
Topological Polar Surface Area	273 Å²
Heavy Atom Count	80
Formal Charge	0
Complexity	1200
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-174922	Azido-PEG24-Tos
HY-133319	Azido-PEG24-Boc
HY-140806-01	Azido-PEG24-alcohol
HY-140762-01	Azido-PEG24-NHS ester
HY-141163	TCO-PEG24-acid
HY-130857	Mal-PEG24-acid
HY-141335	Lipoamido-PEG24-acid
HY-133377	Biotin-PEG24-acid
HY-133323-01	M-PEG24-acid
HY-151820-01	DBCO-PEG24-acid

Alternative Products

Catalog	Name
T17496-01	Azido-PEG24-acid
TCL-01893-01	Azido-PEG24-Tos
T17498-01	Azido-PEG24-Boc
sc-496397	Azido-PEG24-alcohol
516907	Azido-PEG24-Hydroxyl
516886	Azido-PEG24-Hydroxy
T17499	Azido-PEG24-NHS ester
T18074-01	Lipoamido-PEG24-acid
571794	Amino-PEG24-acid
MBS5771139	Mal-PEG24-acid

Azido-PEG24-acid

Chemical Information

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