Rimantadine

CAT: 0804-HY-B0338-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-B0338-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Rimantadine (1-Rimantadine) is an orally active inhibitor for M2 protein, which blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity. Rimantadine significantly inhibits hepatitis A virus (HAV) replication at the post-entry stage in Huh7 cells. Rimantadine enhances autophagy. Rimantadine has a significant protective effect against H3N2 virus in mouse model[1][2].

CAS Number

13392-28-4

Product Name Alternative

1-Rimantadine

UNSPSC

12352211

Hazard Statement

H315, H319, H320

Target

Autophagy; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/rimantadine.html

Purity

99.86

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)N

Molecular Formula

C12H21N

Molecular Weight

179.30

Precautions

H315, H319, H320

References & Citations

[1]Sasaki-Tanaka R, et al., Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy. J Virol. 2022 Sep 28;96 (18) :e0064622.|[2]Simeonova L, et al., Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice. Antiviral Res. 2012 Aug;95 (2) :172-81.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

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