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Ufenamate

CAT: 0804-HY-100009-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100009-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2[1][2][3][4].
CAS Number
67330-25-0
Product Name Alternative
Flufenamic acid butyl ester; Butyl flufenamate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Ufenamate.html
Purity
99.89
Solubility
DMSO : ≥ 44 mg/mL
Smiles
O=C(OCCCC)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2
Molecular Formula
C18H18F3NO2
Molecular Weight
337.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Iino H, et al. Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles. Biol Pharm Bull. 2015;38 (10) :1645-8.|[2]Hayato Iino, et al. Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles. Bio Pharm Bull. 2015;38 (10) :1645-8.|[3]Ting Lü, et al. Photoprotective effect of butyl flufenamate ointment on SKH-1 hairless mice. Chinese Journal of Dermatology ; (12) : 711-715, 2013.|[4]Fan Yang, et al. Topical Application of Butyl Flufenamate Ointment Promotes Cranial Defect Healing in Mice by Inducing BMP2 Secretion in Skin Mesenchymal Stem Cells. Cells. 2022 Nov 15;11 (22) :3620.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-2

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