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SOP1812

CAT: 0804-HY-148012-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148012-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer[1].
CAS Number
2546091-70-5
Product Name Alternative
QN-302
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
G-quadruplex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sop1812.html
Purity
98.46
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(NCCN3CCCC3)=C4C(N(CCCN5CCOCC5)C(C6=CC(C7=CC=C(CN8CCCC8)C=C7)=C(C2=C64)C(N1CCCN9CCOCC9)=O)=O)=O
Molecular Formula
C45H57N7O6
Molecular Weight
791.98
Precautions
H302, H315, H319
References & Citations
[1]Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11 (8) :1634-1644.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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E1982-5mgSOP1812

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