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Inupadenant

CAT: 0804-HY-137442-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137442-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant can not cross BBB. Inupadenant can enhance the humoral immune response and has anti-tumor activity[1][2].
CAS Number
2246607-08-7
Product Name Alternative
EOS-850
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/inupadenant.html
Purity
98.27
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1SC(C2=NC(C3=CC=CO3)=NN2C(N)=N4)=C4N1CCN5CCN(C(C(F)=C6)=CC(OCC[S@](C)=O)=C6F)CC5
Molecular Formula
C25H26F2N8O4S2
Molecular Weight
604.65
References & Citations
[1]Laurence Buisseret, et al. Phase 1 trial of the adenosine A2Areceptor antagonist inupadenant (EOS-850) : Update on tolerability, and antitumor activity potentially associated with the expression of the A2A receptor within the tumor. Journal of Clinical Oncology. Volume 39, Issue 15_suppl.|[2]Tieppo P, et al. 48P The A2AR antagonist inupadenant promotes humoral responses in preclinical models. Immuno-Oncology and Technology, 2024, 24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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