Rabbit anti Human BCRP (ATP-binding cassette sub-family G member 2)

• Background:

  BCRP acts as a xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

• Synonyms:

  Breast cancer resistance Protein, CDw338, Mitoxantrane resistance-associated Protein, Placenta-specific ATP-Binding cassette transporter

• UniProt:

  Q9UNQ0

• Host:

  Rabbit

• Species Reactivity:

  Human

• Isotype:

  Ig

• Conjugation:

  Affinity Purified

• Type:

  Antigen Immunoaffinity Purified Polyclonal

• Applications:

  IHC (paraffin)

• Field of Research:

  Signal Transduction

• Purification Method:

  Antigen Immunoaffinity Purification

• Assay Principle:

  Antibody can be used for immunohistochemistry at 5-10 µg/mL on paraffin-embedded tissues. Optimal concentration should be evaluated by serial dilutions.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Zhou, W., et al. 'The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.' Nat. Med. 2001, 7, 1028-1034. 2. Itoda, M., et al. ''Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.' Drug Metab. Pharmacokinet. 2003, 18, 212-217. 3. Zamber, C.P., et al. 'Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in Human intestine.' Pharmacogenetics 2003, 13, 19-28.

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• CAS Number:

  9007-83-4