Methylthiouracil

• Description :

  Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

• CAS Number :

  [56-04-2]

• Product Name Alternative :

  MTU

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H351, H401

• Target :

  ERK; Interleukin Related; NF-κB; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/methylthiouracil.html

• Concentration :

  10mM

• Purity :

  99.93

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=C(C=C(C)N1)NC1=S

• Molecular Formula :

  C5H6N2OS

• Molecular Weight :

  142.18

• Precautions :

  H317, H351, H401

• References & Citations :

  [1]Ku SK, et al. Anti-inflammatory effects of methylthiouracil in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Nov 1;288 (3) :374-86.|[2]Heeremans A, et al. Elimination profile of methylthiouracil in cows after oral administration. Analyst. 1998 Dec;123 (12) :2629-32.|[3]EAYRS JT, et al. The effect of thyroid deficiency induced by methyl thiouracil on the maturation of the central nervous system. J Anat. 1951 Oct;85 (4) :350-8.|[4]Coda AR, et al. In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis. Eur J Nucl Med Mol Imaging. 2021 Jan;48 (1) :40-52.|[5]Hofstetter HH, et al. Kinetics and organ distribution of IL-17-producing CD4 cells in proteolipid protein 139-151 peptide-induced experimental autoimmune encephalomyelitis of SJL mice. J Immunol. 2007 Feb 1;178 (3) :1372-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  ERK1; ERK2; IL-6; NF-κB; TNFRSF5/CD40