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Methylthiouracil

CAT: 0804-HY-B0513-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0513-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
CAS Number
56-04-2
Product Name Alternative
MTU
UNSPSC
12352005
Hazard Statement
H317, H351, H401
Target
ERK; Interleukin Related; NF-κB; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/methylthiouracil.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C=C(C)N1)NC1=S
Molecular Formula
C5H6N2OS
Molecular Weight
142.18
Precautions
H317, H351, H401
References & Citations
[1]Ku SK, et al. Anti-inflammatory effects of methylthiouracil in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Nov 1;288 (3) :374-86.|[2]Heeremans A, et al. Elimination profile of methylthiouracil in cows after oral administration. Analyst. 1998 Dec;123 (12) :2629-32.|[3]EAYRS JT, et al. The effect of thyroid deficiency induced by methyl thiouracil on the maturation of the central nervous system. J Anat. 1951 Oct;85 (4) :350-8.|[4]Coda AR, et al. In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis. Eur J Nucl Med Mol Imaging. 2021 Jan;48 (1) :40-52.|[5]Hofstetter HH, et al. Kinetics and organ distribution of IL-17-producing CD4 cells in proteolipid protein 139-151 peptide-induced experimental autoimmune encephalomyelitis of SJL mice. J Immunol. 2007 Feb 1;178 (3) :1372-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
ERK1; ERK2; IL-6; NF-κB; TNFRSF5/CD40

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