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IA9

CAT: 0804-HY-P10136-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10136-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IA9 (human TREM-2 182-190) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen -induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research[1][2].
Product Name Alternative
Human TREM-2 182-190
UNSPSC
12352209
Target
TREM receptor
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ia9.html
Purity
98.36
Solubility
DMSO : 22.22 mg/mL (ultrasonic;adjust pH to 4 with 1 M HCL)
Smiles
O=C([C@@H](N)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CCCCN)=O)[C@H](CC)C)=O)CC(C)C)=O)CC1=CC=CC=C1
Molecular Formula
C51H88N10O10
Molecular Weight
1001.31
References & Citations
[1]Sigalov AB. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis. Int J Mol Sci. 2022;23 (16) :8857. Published 2022 Aug 9.|[2]Zonghua Luo, et al. Development of a Ga-68 Labeled Peptide Tracer Targeting TREM2 for Neuroinflammation PET Imaging. Journal of Nuclear Medicine. Jun 2025, 66 (supplement 1) 251786.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
TREM-2

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