TF-S14

• Description :

  TF-S14 is a reverse agonist of RORγt. TF-S14 reduces Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22 by binding to and inhibiting RORγt activity. TF-S14 can be used in the study of autoimmune diseases and rejection in allotransplantation[1].

• CAS Number :

  [2425563-60-4]

• UNSPSC :

  12352005

• Target :

  ROR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/tf-s14.html

• Smiles :

  O=C(N1CC[C@@H](C)C[C@H]1C)C2=C(NC(C3=CN=CC=C3)=O)SC4=C2CCCC4

• Molecular Formula :

  C22H27N3O2S

• Molecular Weight :

  397.53

• References & Citations :

  [1]Fouda A, et al. RORγt inverse agonist TF-S14 inhibits Th17 cytokines and prolongs skin allograft survival in sensitized mice[J]. Communications Biology, 2024, 7 (1) : 454.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported