Lin28-let-7 antagonist 1

• UNSPSC Description:

  Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lin28-let-7-antagonist-1.html

• Purity:

  99.68

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CN(C(C)=O)C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1

• Molecular Weight:

  281.319

• References & Citations:

  [1]Roos M, et al. A Small-Molecule Inhibitor of Lin28. ACS Chem Biol. 2016 Oct 21;11(10):2773-2781.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  108825-65-6