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Vonoprazan

CAT: 0804-HY-100007-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100007-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+, K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori[1][2][3].
CAS Number
881681-00-1
Product Name Alternative
TAK-438 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Proton Pump
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/TAK-438-free-base.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O
Molecular Formula
C17H16FN3O2S
Molecular Weight
345.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB) . J Med Chem, 2012, 55 (9), 4446-4456.|[2]Hori Y, et al. 1-[5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335 (1), 231-238.|[3]Sugimoto M, et al. Role of Vonoprazan in Helicobacter pylori Eradication Therapy in Japan. Front Pharmacol. 2019 Jan 15;9:1560.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Br J Clin Pharmacol. 2019 Jul;85 (7) :1454-1463.|Int J Nanomedicine. 2025 Jun 24:20:8063-8083.|Toxicol Appl Pharmacol. 2024 May:486:116945.|Drug Dev Res. 2022 Dec 9.|Drug Metab Dispos. 2016 Oct;44 (10) :1543-9. |Eur J Med Chem. 2024 Dec 5:279:116842.

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