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Daucosterol

CAT: 0804-HY-N0410-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0410-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway[1][2][3].
CAS Number
474-58-8
Product Name Alternative
Eleutheroside A; β-Sitosterol β-D-glucoside
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Autophagy; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Daucosterol.html
Purity
93.98
Solubility
DMSO : 3.33 mg/mL (ultrasonic)
Smiles
C[C@H](CC[C@@H](CC)C(C)C)[C@](CC1)([H])[C@]2(C)[C@]1([H])[C@]([C@]3([H])CC2)([H])CC=C([C@]3(C)CC4)C[C@H]4O[C@@]5([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5
Molecular Formula
C35H60O6
Molecular Weight
576.85
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jiang LH, et al. Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway. J Steroid Biochem Mol Biol. 2015 Aug;152:45-52.|[2]Zhao C, et al. Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner. Life Sci. 2015 Sep 15;137:37-43. |[3]Gao P, et al. Daucosterol induces autophagic-dependent apoptosis in prostate cancer via JNK activation. Biosci Trends. 2019 May 12;13 (2) :160-167. |[4]Wang GQ, et al. Daucosterol inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway. Bangladesh Journal of Pharmacolog, 2016, 11 (2) : 395-401.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
GTR19170711-01Daucosterol

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