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(±) -Naringenin

CAT: 0804-HY-W011641-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W011641-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(±) -Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±) -Naringenin promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research[1][2][3].
CAS Number
67604-48-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; NF-κB; Potassium Channel; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/racemic-naringenin.html
Purity
99.83
Solubility
DMSO : 120 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C1CC(C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13
Molecular Formula
C15H12O5
Molecular Weight
272.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Saponara S, et al. (+/-) -Naringenin as large conductance Ca (2+) -activated K+ (BKCa) channel opener in vascular smooth muscle cells. Br J Pharmacol. 2006 Dec;149 (8) :1013-21.|[2]Wei Dou, et al. Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling. Br J Nutr. 2013 Aug;110 (4) :599-608.|[3]Mahzad Motallebi, et al. Naringenin: A potential flavonoid phytochemical for cancer therapy. Life Sci. 2022 Sep 15:305:120752.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 1
Isoform
Caspase 9; NF-κB

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