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Scyllatoxin

CAT: 0804-HY-P3064Size: 1 EachDry Ice: NoHazardous: No
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Description
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus) . Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].
CAS Number
142948-19-4
Product Name Alternative
Leiurotoxin I
UNSPSC
12352209
Hazard Statement
H301-H311-H330
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/scyllatoxin.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]1CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC3=CNC=N3)=O)CCCCN)=O)C(C)C)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)CSSC[C@H](NC4=O)C(N[C@H]2CCC(O)=O)=O)=O)CCSC)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)=O)CSC[C@H](NC1=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]4CCCCN)=O)CC(O)=O)=O)=O)[C@H](CC)C)=O)=O)CC5=CC=CC=C5
Molecular Formula
C142H237N45O39S7
Molecular Weight
3423.15
Precautions
P260-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
References & Citations
[1]Auguste P, et al. Scyllatoxin, a blocker of Ca (2+) -activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 1992 Jan 28;31 (3) :648-54.|[2]Akiyama T, et al. Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla. Neurochem Int. 2010 Jan;56 (2) :263-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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