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Fenbendazole (Standard)

CAT: 0804-HY-B0413R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0413R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fenbendazole (Standard) is the analytical standard of Fenbendazole. This product is intended for research and analytical applications. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1].
CAS Number
43210-67-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; HIF/HIF Prolyl-Hydroxylase; Microtubule/Tubulin; Parasite; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fenbendazole-standard.html
Purity
99.90
Smiles
O=C(OC)NC1=NC2=CC=C(SC3=CC=CC=C3)C=C2N1
Molecular Formula
C15H13N3O2S
Molecular Weight
299.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Nilambra Dogra, et al. Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Sci Rep. 2018 Aug 9;8 (1) :11926.|[2]Qiwen Duan, et al. Fenbendazole as a potential anticancer drug. Anticancer Res. 2013 Feb;33 (2) :355-62.|[3]Hossein Aleyasin, et al. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxid Redox Signal. 2015 Jan 10;22 (2) :121-34.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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