CTEP

CAT: 0804-HY-15445-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15445-01Size:5 mg
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Description
CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors. CTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[871362-31-1]
Product Name Alternative
RO 4956371; mGluR5 inhibitor
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CTEP.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(F)(F)OC1=CC=C(N2C(C)=C(C#CC3=CC(Cl)=NC=C3)N=C2C)C=C1
Molecular Formula
C19H13ClF3N3O
Molecular Weight
391.77
Precautions
H302, H315, H320, H335
References & Citations
[1]Lindemann L, et al. CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. J Pharmacol Exp Ther. 2011 Nov;339 (2) :474-86.|[2]Michalon A, et al. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron. 2012 Apr 12;74 (1) :49-56.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5

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