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LH846

CAT: 0804-HY-15704-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15704-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
CAS Number
639052-78-1
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LH846.html
Purity
98.89
Solubility
DMSO : ≥ 33.33 mg/mL
Smiles
O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3
Molecular Formula
C16H13ClN2OS
Molecular Weight
316.81
Precautions
H302, H413
References & Citations
[1]Lee JW, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50 (45) :10608-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1

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B1237-50LH846
217251Casein Kinase I Inhibitor V, LH846 (N- (5-Chloro-6-methyl-1,3-benzothiazol-2-yl) -2-phenylacetamide) (N- (5-Chloro-6-methylbenzo[d]thiazol-2-yl) -2-phenylacetamide) discontinued

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