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FK960

CAT: 0804-HY-118275-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118275-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FK960 is a potential anti-dementia agent that reverses the reduction in cerebral blood flow (rCBF) caused by sensory stimulation by enhancing cholinergic neurotransmission. In macaque experiments, physostigmine (AChE inhibitor; HY-N6608) was able to completely eliminate the rCBF in the sensory cortex increased by vibrotactile stimulation. FK960 (1-1000 μg/kg) can restore the eliminated rCBF response, and the action time can last for 1 hour. However, FK960 cannot restore the rCBF response eliminated by HA-966 (NMDA modulator; HY-100822), indicating that its function is not dependent on non-glutamatergic neurotransmission.
CAS Number
133920-70-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fk960.html
Smiles
O=C(C1=CC=C(C=C1)F)NN2CCN(CC2)C(C)=O
Molecular Formula
C13H16FN3O2
Molecular Weight
265.28
Precautions
P261-P280-P302+P352
References & Citations
[1]FK960 [N- (4-acetyl-1-piperazinyl) -p-fluorobenzamide monohydrate], a novel potential antidementia drug, restores the regional cerebral blood flow response abolished
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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