7-Chloro-4-(piperazin-1-yl)quinoline
CAT:
804-HY-W020111-01
Size:
50 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
7-Chloro-4-(piperazin-1-yl)quinoline
- CAS Number: 837-52-5
- UNSPSC Description: 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1].
- Target Antigen: Parasite; Sirtuin
- Type: Reference compound
- Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Epigenetics
- Applications: COVID-19-anti-virus
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/7-chloro-4-piperazin-1-yl-quinoline.html
- Purity: 98.63
- Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: ClC1=CC2=C(C(N3CCNCC3)=CC=N2)C=C1
- Molecular Weight: 247.729
- References & Citations: [1]Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported