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Spantide II

CAT: 0804-HY-P1722-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1722-01Size:5 mg
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Description
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3].
CAS Number
129176-97-2
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/spantide-ii.html
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCCC)=O)=O)CC2=CNC3=CC=CC=C23)=O)[C@H](NC([C@H](CC(N)=O)NC([C@H](NC([C@H](CCC4)N4C([C@H](CC5=CN=CC=C5)NC([C@H](CCC6)N6C([C@H](N)CCCCNC(C7=CN=CC=C7)=O)=O)=O)=O)=O)CC(C=C8)=CC(Cl)=C8Cl)=O)=O)CC9=CNC%10=CC=CC=C9%10
Molecular Formula
C86H104Cl2N18O13
Molecular Weight
1668.76
References & Citations
[1]Xu XJ, et al. Spantide II, a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw. Neuroscience. 1991;42 (3) :731-7. |[2]Kikwai L, et al. In vitro and in vivo evaluation of topical formulations of spantide II. AAPS PharmSciTech. 2005 Oct 31;6 (4) :E565-72. |[3]Babu RJ, et al. Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II. Pharm Res. 2004 Jan;21 (1) :108-13.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NK1R

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