Anti-Hsp90 beta Antibody

Anti-Hsp90 beta Antibody

• Description: Rabbit Polyclonal Antibody specific to Hsp90 beta
• Product Name Alternative: HSP 90, Heat shock 84 kDa, HSP 84, HSP84
• CAS Number: 9007-83-4
• Gene Name: HSP90AB1
• Gene ID: 3326
• NCBI Gene ID: HSP90AB1
• UniProt: P08238
• Accession Number: NP_031381.2
• Cellular Locus: Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane, Dynein axonemal particle
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: Purified recombinant human Hsp90beta
• Target Antigen: Heat shock protein HSP 90-beta
• Target: Hsp90 beta
• Clonality: Polyclonal
• Type: Antibody
• Applications: WB, IHC, ICC/IF, ELISA
• Field of Research: Heat Shock& Stress Proteins
• Purification Method: Whole antiserum
• Concentration: Lot Specific
• Dilution: Dilute in PBS or medium which is identical to that used in the assay system.
• Format: Whole Antiserum
• Form: Liquid
• Buffer: Whole Antiserum
• Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate rPubMed:16478993, PubMed:18239673, PubMed:19696785, PubMed:20353823, PubMed:24613385, PubMed:32272059, PubMed:25973397, PubMed:26991466, PubMed:27295069}.
• Additionnal Information: Immunoblotting: use at 1:20,000- 1:40,000 (ECL). A band of ~90 kDa is detected.
  
  Positive control: HeLa cell lysate
• Storage Conditions: This antibody is stable for at least one (1) year at -20°C.
• Specificity: This antibody recognizes human, rat, and mouse Hsp90b. It does not cross- react with Hsp90alpha.
• Formulation: Whole antiserum
• Target Background: Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Hsp90 is involved in the folding, assembly, maturation, and stabilization of specific proteins as a member of a chaperone complex. It is also highly expressed in unstressed cells where it participates in controlling the activity, turnover, and trafficking of a variety of proteins. Most of the Hsp90-regulated proteins are involved in cell signaling and include the kinases, v-Src, Wee1, c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of hepatitis B virus and telomerase.