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Xylitol

CAT: 0804-HY-N0538-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N0538-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model[1][2][3][4].
CAS Number
87-99-0
Product Name Alternative
Xylite
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Atg7; Atg8/LC3; Autophagy; Bacterial; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/xylitol.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 110 mg/mL (ultrasonic)
Smiles
OC[C@@H](O)[C@H](O)[C@@H](O)CO
Molecular Formula
C5H12O5
Molecular Weight
152.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Cannon M, et al. Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models[J]. Nutraceuticals, 2025, 5 (1) : 4.|[2]Uebanso T, et al. Effects of consuming xylitol on gut microbiota and lipid metabolism in mice[J]. Nutrients, 2017, 9 (7) : 756.|[3]Park E, et al. Xylitol induces cell death in lung cancer A549 cells by autophagy. Biotechnol Lett. 2015 May;37 (5) :983-90.|[4]Uittamo J, et al. Xylitol inhibits carcinogenic acetaldehyde production by Candida species. Int J Cancer. 2011 Oct 15;129 (8) :2038-41.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

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