Xylitol

• Description :

  Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model[1][2][3][4].

• Product Name Alternative :

  Xylite

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Atg7; Atg8/LC3; Autophagy; Bacterial; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Autophagy; Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/xylitol.html

• Purity :

  99.87

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 110 mg/mL (ultrasonic)

• Smiles :

  OC[C@@H](O)[C@H](O)[C@@H](O)CO

• Molecular Formula :

  C5H12O5

• Molecular Weight :

  152.15

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Cannon M, et al. Effects of Xylitol on Tumor Progression in Syngeneic Mice Cancer Models[J]. Nutraceuticals, 2025, 5 (1) : 4.|[2]Uebanso T, et al. Effects of consuming xylitol on gut microbiota and lipid metabolism in mice[J]. Nutrients, 2017, 9 (7) : 756.|[3]Park E, et al. Xylitol induces cell death in lung cancer A549 cells by autophagy. Biotechnol Lett. 2015 May;37 (5) :983-90.|[4]Uittamo J, et al. Xylitol inhibits carcinogenic acetaldehyde production by Candida species. Int J Cancer. 2011 Oct 15;129 (8) :2038-41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [87-99-0]