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Bakuchiol

CAT: 0804-HY-N0235-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0235-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) [2] and human carboxylesterase 2 (hCE2) [3], with IC50s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory[5], antibacterial[4], antitumor[1] therapies, as well as drug metabolism regulation.
CAS Number
10309-37-2
Product Name Alternative
(S) - (+) -Bakuchiol
UNSPSC
12352005
Hazard Statement
H400, H410
Target
Autophagy; Carboxylesterase (CES) ; p38 MAPK; UGT
Type
Natural Products
Related Pathways
Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Bakuchiol.html
Purity
99.25
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
OC1=CC=C(/C=C/[C@](C)(C=C)CC/C=C(C)\C)C=C1
Molecular Formula
C18H24O
Molecular Weight
256.38
Precautions
H400, H410
References & Citations
[1]Chen Z, et al. Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol. 2010 Sep 25;643 (2-3) :170-9.|[2]Xu Y, et al. In vitro evidence for bakuchiol's influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr Health Sci. 2014 Sep;14 (3) :564-9.|[3]Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106.|[4]Lau KM, et al. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine. 2014 Jun 15;21 (7) :942-5.|[5]Yao HB, et al. Anti-Allergic and Anti-inflammatory Effects of Bakuchiol on Ovalbumin-Induced Allergic Rhinitis in Mice. Appl Biochem Biotechnol. 2024;196 (6) :3456-3470.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 1

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