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Sanguinarine

CAT: 0026-B2946-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2946-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sanguinarine is a benzylisoquinoline alkaloid that inhibits PP2C and shows selectivity for PP2C over PP1, PP2A, and PP2B in vitro. It inhibits MKP-1 with an IC₅₀ of 10 μM and shows selectivity for MKP-1 over MKP-3. It is a potent suppressor of NF-κB activation and inhibits the TNF-dependent activation of NF-κB in a dose-dependent manner, with maximum effect occurring at 10 μM. It shows cytotoxicity toward human promyelocytic leukemia cell line HL60, with an IC₅₀ value of 0.37 μM.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36months

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T2781-01Sanguinarine
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GTR19153851Sanguinarine Sulfate

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