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BUR1

CAT: 0804-HY-121025-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121025-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline induced rats[1].
CAS Number
23000-46-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bur1.html
Purity
99.65
Solubility
10 mM in DMSO
Smiles
C12=NC=NC(N3CCCCC3)=C1C=NN2C4=CC=CC=C4
Molecular Formula
C16H17N5
Molecular Weight
279.34
Precautions
H315, H319, H335
References & Citations
[1]Xing Y, et al. A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels. Eur Respir J. 2018 Apr 4;51 (4) :1702229.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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