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CINK4

CAT: 0026-B2929-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2929-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CINK4 is a triaminopyrimidine derivative that inhibits Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC₅₀ values of 1.5 and 5.6 μM, respectively. It reduces retinoblastoma protein phosphorylation at Ser780 and Ser795 and induces cell cycle arrest in the G1 phase in U2OS and MRC-5 cells at 5-10 µM. Administration of CINK4 at 30 mg/kg, i.p. for 29 days, suppresses tumor growth in mice bearing human HCT116 colon carcinoma xenografts.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

Alternative Products

CatalogName
444076Cdk4/6 Inhibitor IV (CINK4)

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