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Xanomeline

CAT: 0804-HY-105182-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105182-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].
CAS Number
131986-45-3
Product Name Alternative
LY-246708
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/xanomeline.html
Purity
99.95
Solubility
DMSO : 25 mg/mL (ultrasonic) |Ethanol : ≥ 100 mg/mL
Smiles
CCCCCCOC1=NSN=C1C2=CCCN(C)C2
Molecular Formula
C14H23N3OS
Molecular Weight
281.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Kreir M, et al. Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons. Eur J Pharmacol. 2019;858:172474|[2]Shekhar A, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 2008;165 (8) :1033-1039.|[3]Andersen MB, et al. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys. Neuropsychopharmacology. 2003;28 (6) :1168-1175.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
MAChR1; mAChR4

Alternative Products

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BA5484-25Xanomeline
CS-O-63563Xanomeline-d11
CS-EK-00836Xanomeline metabolite A
abx283210-01Xanomeline tartrate

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