Xanomeline

• Description :

  Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].

• Product Name Alternative :

  LY-246708

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/xanomeline.html

• Purity :

  99.95

• Solubility :

  DMSO : 25 mg/mL (ultrasonic) |Ethanol : ≥ 100 mg/mL

• Smiles :

  CCCCCCOC1=NSN=C1C2=CCCN(C)C2

• Molecular Formula :

  C14H23N3OS

• Molecular Weight :

  281.42

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kreir M, et al. Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons. Eur J Pharmacol. 2019;858:172474|[2]Shekhar A, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 2008;165 (8) :1033-1039.|[3]Andersen MB, et al. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys. Neuropsychopharmacology. 2003;28 (6) :1168-1175.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 4

• Isoform :

  MAChR1; mAChR4

• CAS Number :

  [131986-45-3]