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Afoxolaner (Standard)

CAT: 0804-HY-16974R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16974R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afoxolaner (Standard) is the analytical standard of Afoxolaner. This product is intended for research and analytical applications. Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].
CAS Number
1093861-60-9
UNSPSC
12352005
Target
Chloride Channel; GABA Receptor; Parasite; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/afoxolaner-standard.html
Smiles
O=C(C1=C2C=CC=CC2=C(C3=NOC(C(F)(F)F)(C4=CC(C(F)(F)F)=CC(Cl)=C4)C3)C=C1)NCC(NCC(F)(F)F)=O
Molecular Formula
C26H17ClF9N3O3
Molecular Weight
625.87
References & Citations
[1]Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201 (3-4) :223-5.|[2]Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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