CD40 ligand rabbit pAb

Disease:Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM) . HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence., function:Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching., function:Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway., online information:CD40L defect database, PTM:N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40., PTM:Not O-glycosylated., PTM:The soluble form derives from the membrane form by proteolytic processing., similarity:Belongs to the tumor necrosis factor family., subunit:Homotrimer., tissue specificity:Specifically expressed on activated CD4+ T-lymphocytes.

Disease: Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM: 308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. function: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. function: Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. online information: CD40L defect database, PTM: N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. PTM: Not O-glycosylated. PTM: The soluble form derives from the membrane form by proteolytic processing. similarity: Belongs to the tumor necrosis factor family. subunit: Homotrimer. tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes.

P29965

P29965

Human; Rat; Mouse

Synthesized peptide derived from human CD40 ligand

Rabbit

WB; ELISA

1 mg/ml

WB 1:1000-2000 ELISA 1:5000-20000

-20°C/1 year

IgG

Cell membrane ; Single-pass type II membrane protein . Cell surface .; [CD40 ligand, soluble form]: Secreted . Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. .

CD40 ligand (CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5; CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form]