Imipenem

• UNSPSC Description:

  Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/imipenem.html

• Purity:

  99.83

• Solubility:

  H2O : 17.5 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O

• Molecular Weight:

  299.35

• References & Citations:

  [1]Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808.|[2]F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4.|[3]Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90.Antimicrob Agents Chemother. 2023 Sep 6;e0052823.|Antimicrob Agents Chemother. 2024 Jan 4:e0133223.|Cell Host Microbe. 2024 May 13:S1931-3128(24)00137-9.|Emerg Microbes Infect. 2024 Dec;13(1):2321981.|Int J Antimicrob Agents. 3 September 2022, 106669.|iScience. 2023 Oct 5.|Microbiol Spectr. 2023 Nov 20:e0304723.|Microorganisms. 2024 Mar 13, 12(3), 575.|Nat Commun. 2023 Mar 22;14(1):1594.|Open Forum Infect Dis. 2023 Jan 27.|Res Sq. 2024 Nov 26.|Vet Microbiol. 2024 May, 292, 110046.|Animal Diseases. 02 November 2021.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Commun Biol. 2023 Aug 12;6(1):837.|Free Radic Biol Med. 2024 May 2:S0891-5849(24)00435-0.|J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.|J Cachexia Sarcopenia Muscle. 2023 Mar 8.|Nat Commun. 2022 Mar 2;13(1):1116.|Sci Rep. 2022 Oct 7;12(1):16814.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  64221-86-9