L-Palmitoylcarnitine-d3-1 (hydrochloride)

L-Palmitoylcarnitine-d3-1 (hydrochloride)

• CAS Number: 2692623-98-4
• UNSPSC Description: L-Palmitoylcarnitine-d3-1 (hydrochloride) is deuterium labeled L-Palmitoylcarnitine (chloride). L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1][2].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; Potassium Channel
• Type: Isotope-Labeled Compounds
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Others
• Field of Research: Cardiovascular Disease
• Smiles: [2H]C([2H])([2H])CCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O.Cl
• Molecular Weight: 439.09
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported