L-Palmitoylcarnitine-d3-1 (hydrochloride)

• UNSPSC Description:

  L-Palmitoylcarnitine-d3-1 (hydrochloride) is deuterium labeled L-Palmitoylcarnitine (chloride). L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1][2].

• Target Antigen:

  Endogenous Metabolite; Isotope-Labeled Compounds; Potassium Channel

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Others

• Field of Research:

  Cardiovascular Disease

• Smiles:

  [2H]C([2H])([2H])CCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O.Cl

• Molecular Weight:

  439.09

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2692623-98-4