M6PR (cation dependent) Recombinant Rabbit Monoclonal Antibody [PSH01-06]

M6PR (cation dependent) Recombinant Rabbit Monoclonal Antibody [PSH01-06]

• Description: In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene. The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for transport to the lysosome. Homologues of CD-MPR are found in all eukaryotes. Both CD-MPRs and CI-MPRs are lectins that bind their M6P-tagged cargo in the lumen of the Golgi apparatus. The CD-MPR shows greatly enhanced binding to M6P in the presence of divalent cations, such as manganese. The MPRs (bound to their cargo) are recognized by the GGA family of clathrin adaptor proteins and accumulate in forming clathrin-coated vesicles. They are trafficked to the early endosome where, in the relatively low pH environment of the endosome, the MPRs release their cargo. The MPRs are recycled back to the Golgi, again by way of interaction with GGAs and vesicles. The cargo proteins are then trafficked to the lysosome via the late endosome independently of the MPRs.
• Product Name Alternative: 46 kDa mannose 6 phosphate receptor antibody 46 kDa mannose 6-phosphate receptor antibody Cation dependent mannose 6 phosphate receptor antibody Cation dependent mannose 6 phosphate receptor precursor antibody Cation-dependent mannose-6-phosphate receptor antibody CD Man 6 P receptor antibody CD Man-6-P receptor antibody CD MPR antibody CD-M6PR antibody CD-MPR antibody FLJ32994 antibody M6pr antibody M6PR protein antibody Man6PR antibody Mannose 6 phosphate receptor (cation dependent) antibody Mannose 6 phosphate receptor antibody MPR 46 antibody MPR46 antibody MPRD antibody MPRD_HUMAN antibody Mr 46,000 Man6PR antibody Small mannose 6 phosphate receptor antibody SMPR antibody
• Abbreviation: M6PR, MPR46, MPRD
• CAS Number: 9000-83-3
• Swiss Prot: P20645 Human, P24668 Mouse, Q6AY20 Rat
• Cellular Locus: Lysosome membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human M6PR aa 1-200 / 277.
• Isotype: IgG
• Clone: PSH01-06
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: A549 cell lysate, PC-12 cell lysate, mouse kidney tissue lysate, rat kidney tissue lysate, human kidney tissue, human liver tissue, rat kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 31 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes