Dinitolmide

• Description:

  Dinitolmide (Zoalene) is an orally active anticoccidial agent used as a fodder additive. Dinitolmide has a wide anticoccidial spectrum with no effect on host immunity. Dinitolmide mainly acts on the first generation merozoite stage of coccidia and also has an inhibitory effect on the sporulation process of oocysts. Dinitolmide has anti-Toxoplasma gondii effect in vitro with an EC50 of 3.625 μg/mL. Dinitolmide can be used to inhibits infections caused by Eimeria tenella[1][2].

• Product Name Alternative:

  Zoalene

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Dinitolmide.html

• Concentration:

  10mM

• Purity:

  99.66

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C (N) C1=CC ([N+] ([O-]) =O) =CC ([N+] ([O-]) =O) =C1C

• Molecular Formula:

  C8H7N3O5

• Molecular Weight:

  225.16

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Qu D, et al. Effect of dinitolmide intercalated into Montmorillonite on E. tenella infection in chickens. Parasitol Res. 2014 Mar;113 (3) :1233-8.|[2]Cao X, et al. In vitro anti-Toxoplasma gondii effects of a coccidiostat dinitolmide. Vet Parasitol. 2023 Apr;316:109903.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Coccidia; Toxoplasma

• CAS Number:

  148-01-6