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Pargyline

CAT: 0804-HY-A0091A-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0091A-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities[1][2][3]. Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
555-57-7
UNSPSC
12352005
Hazard Statement
H227, H301+H311+H331, H315, H319, H335
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Pargyline.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C#CCN(C)CC1=CC=CC=C1
Molecular Formula
C11H13N
Molecular Weight
159.23
Precautions
H227, H301+H311+H331, H315, H319, H335
References & Citations
[1]C J Fowler, et al. The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline. Biochem Pharmacol. 1982 Nov 15;31 (22) :3555-61.|[2]Hyung Tae Lee, et al. Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncol Rep. 2013 Oct;30 (4) :1587-92.|[3]Fuentes JA, et al. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. Eur J Pharmacol. 1979 Jul 15;57 (1) :21-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAO-A; MAO-B
Citation 01
J Parkinson Dis. 2020;10 (2) :523-542.|Neural Regen Res. 2021 Aug;16 (8) :1660-1670.|Parkinsons Dis. 2022 Nov 14:2022:1428817.

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